Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.38 |
| ▸ | HCK | P08631 | 3/20 | 0.36 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | CTSV | O60911 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752382 | 0.91 | HPGDS (0.47) | HPGDSCTSLCTSSCTSBCDK2 | |
| SCHEMBL6752300 | 0.87 | CTSK (0.46) | HCKNR2C2BTKCTSLCTSS | |
| SCHEMBL6747834 | 0.82 | HPGDS (0.44) | HPGDSCTSLCTSSCTSBCTSK | |
| SCHEMBL6752285 | 0.81 | HPGDS (0.39) | HPGDSHCKNR2C2BTKCTSL | |
| SCHEMBL6752290 | 0.80 | CTSL (0.46) | HPGDSCTSL | |
| SCHEMBL6749630 | 0.80 | HPGDS (0.39) | HPGDSCTSLCTSSCTSBCTSK | |
| SCHEMBL6985444 | 0.79 | HPGDS (0.39) | HPGDSCTSLCTSSCTSBCTSK | |
| SCHEMBL6751642 | 0.79 | CTSL (0.45) | HPGDSCTSLCTSSCTSBCTSK | |
| SCHEMBL6747703 | 0.79 | CTSL (0.40) | HPGDSCTSLCTSSCTSBCTSK | |
| SCHEMBL6749624 | 0.77 | F10 (0.43) | HPGDSSIRT2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127549-A1 | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127549-A1 | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases | CPN1, CTRL, CPA1 | HPGDS 1248/4885HCK 537/4885NR2C2 3903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.