Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12061505 | 1.00 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL12061510 | 1.00 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL10416031 | 0.82 | ALDH1A1 (0.52) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL8762226 | 0.82 | GABRA1 (0.36) | ALDH1A1CYP1A2CA1CA2 | |
| SCHEMBL25887 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL11672371 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL6248166 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL29170899 | 0.78 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL17789903 | 0.78 | AOC3 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 | |
| SCHEMBL15669160 | 0.77 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C9CYP2C19AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183415-B2 | Methods of synthesizing cinacalcet and salts thereof | AMGEN, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110281954-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281954-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | ACE, SI, REN | ALDH1A1 1814/4885CYP1A2 2370/4885CYP2C9 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.