Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL29530543 | 1.00 | ABCC4 (0.45) | ABCC4MAPTLMNATSHRNFKB1 | |
| Valeric Acid SCHEMBL28231350 | 0.91 | AKR1B1 (0.47) | MAPTLMNATSHRGPR84FFAR1 | |
| Acrylic Acid SCHEMBL30360549 | 0.87 | LMNA (0.53) | LMNATSHRFFAR1ALDH1A1TDP1 | |
| Acrylic Acid SCHEMBL5512672 | 0.87 | LMNA (0.53) | LMNATSHRFFAR1ALDH1A1TDP1 | |
| Acrylic Acid SCHEMBL11114820 | 0.87 | LMNA (0.53) | LMNATSHRFFAR1ALDH1A1TDP1 | |
| Acrylic Acid SCHEMBL29589240 | 0.87 | LMNA (0.53) | LMNATSHRFFAR1ALDH1A1TDP1 | |
| Acrylic Acid SCHEMBL8864275 | 0.87 | LMNA (0.53) | LMNATSHRFFAR1ALDH1A1TDP1 | |
| Acrylic Acid SCHEMBL230728 | 0.87 | LMNA (0.53) | LMNATSHRFFAR1ALDH1A1TDP1 | |
| Adipic Acid SCHEMBL3475386 | 0.87 | LMNA (0.58) | LMNATSHRNFKB1PMP22GPR84 | |
| Adipic Acid SCHEMBL230983 | 0.87 | LMNA (0.58) | LMNATSHRNFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6714712-B2 | URETHANE-FREE POLYESTER ACRYLATE OLIGOMERS HAVE ALSO BEEN USED IN RADIATION-CURABLE COATING COMPOSITIONS FOR OPTICAL GLASS FIBERS | DSM N.V. (NL) | 2004-03-30 | — | — | US | disclosed |
| EP-1385893-A2 | RADIATION CURABLE COATING COMPOSITION | DSM IP Assets B.V. (NL) | 2004-02-04 | — | — | EP | disclosed |
| US-20020168164-A1 | Radiation curable coating composition | DSM IP ASSETS B.V. (NL) | 2002-11-14 | — | — | US | disclosed |
| WO-2002055574-A2 | RADIATION CURABLE COATING COMPOSITION | DSM NV (NL) | 2002-07-18 | — | — | WO | disclosed |
| US-4272607-A | POLYMER OF A TETRAHYDROFURFURYL ACRYLATE, UNSATURATED COMPOUND AND INITIATOR | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1981-06-09 | — | — | US | disclosed |