Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.52 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.52 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | PPM1D | O15297 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473735 | 0.84 | HDAC8 (0.48) | HIF1AMRGPRX4HDAC8HDAC6 | |
| SCHEMBL14420824 | 0.80 | LOXL2 (0.58) | HIF1ALOXL2CYP4F2CYP4A11SENP1 | |
| SCHEMBL15761753 | 0.79 | HIF1A (0.85) | HIF1ALOXL2CYP4F2CYP4A11SENP1 | |
| SCHEMBL8716267 | 0.78 | LOXL2 (0.56) | HIF1ALOXL2CYP4F2CYP4A11SLC7A5 | |
| SCHEMBL15761746 | 0.78 | HIF1A (0.60) | HIF1ALOXL2CYP4F2CYP4A11SENP1 | |
| SCHEMBL15755934 | 0.77 | HIF1A (0.58) | HIF1ALOXL2CYP4F2CYP4A11SENP1 | |
| SCHEMBL15761754 | 0.77 | HIF1A (0.58) | HIF1ALOXL2CYP4F2CYP4A11SENP1 | |
| SCHEMBL21579366 | 0.77 | LOXL2 (0.70) | HIF1ALOXL2CYP4F2CYP4A11SENP1 | |
| SCHEMBL308038 | 0.76 | LOXL2 (0.64) | HIF1ALOXL2CYP4F2CYP4A11SENP1 | |
| SCHEMBL45633 | 0.75 | LOXL2 (0.68) | HIF1ALOXL2CYP4F2CYP4A11SENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004505014-A | — | — | 2004-02-19 | — | — | JP | claimed |
| EP-1268463-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001077097-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-10-18 | — | — | WO | claimed |