Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865937 | 0.76 | RECQL (0.45) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2986380 | 0.75 | KDM4E (0.55) | ALDH1A1GAAMAPTHTTATM | |
| SCHEMBL18160982 | 0.75 | KDM4E (0.55) | ALDH1A1GAAMAPTHTTATM | |
| SCHEMBL2986381 | 0.75 | KDM4E (0.55) | ALDH1A1GAAMAPTHTTATM | |
| SCHEMBL18160977 | 0.75 | KDM4E (0.55) | ALDH1A1GAAMAPTHTTATM | |
| SCHEMBL22065499 | 0.75 | KDM4E (0.55) | ALDH1A1GAAMAPTHTTATM | |
| SCHEMBL9512577 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPTNFE2L2L3MBTL1PTGS1 | |
| SCHEMBL7867492 | 0.74 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTL3MBTL1FBP1 | |
| SCHEMBL3227313 | 0.74 | NFE2L2 (0.42) | NFE2L2HSD11B1APPPTGS1FBP1 | |
| SCHEMBL3981306 | 0.74 | HSD17B10 (0.46) | GAAFBP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743790-B2 | A UREA OR THIOUREA DERIVATIVES CONTAINING AMIDE GROUP USEFUL AS ANTICOAGULANTS AND ANTIINFLAMMATORY AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-06-01 | — | — | US | disclosed |
| EP-1299354-A2 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | Aventis Pharma Deutschland GmbH (DE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001094301-A2 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-12-13 | — | — | WO | disclosed |
| EP-1162194-A1 | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use | Aventis Pharma Deutschland GmbH (DE) | 2001-12-12 | — | — | EP | disclosed |
| EP-0253536-A2 | Fluorobenzyl esters | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-01-20 | — | — | EP | disclosed |