SCHEMBL6762255

SCHEMBL6762255

CO[Si](Br)(c1ccccc1)[Si](C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
CA4 P22748 1/20 0.33
MAPT P10636 1/20 0.32
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18108503 0.76 ESR1 (0.38) ESR1ESR2CA4MAPTPOLB
SCHEMBL8414146 0.76 ESR1 (0.38) ESR1ESR2CA4MAPTPOLB
SCHEMBL18108221 0.73 CA4 (0.38) ESR1ESR2CA4MAPTPOLB
SCHEMBL8637616 0.73 ESR1 (0.39) ESR1ESR2CA4MAPTPOLB
SCHEMBL17835393 0.73 CA4 (0.38) ESR1ESR2CA4MAPTPOLB
SCHEMBL18108065 0.73 CA4 (0.38) ESR1ESR2CA4MAPTPOLB
SCHEMBL648335 0.72 CA4 (0.41) ESR1ESR2CA4MAPTPOLB
SCHEMBL8639620 0.71 ESR1 (0.38) ESR1ESR2CA4MAPTPOLB
SCHEMBL9466367 0.70 ESR1 (0.41) ESR1ESR2CA4MAPTPOLB
SCHEMBL48955 0.70 ESR1 (0.41) ESR1ESR2CA4MAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6803469-B2 CYCLIZING IN THE PRESENCE OF A SILYLATING AGENT THE PROCTER & GAMBLE COMPANY 2004-10-12 US claimed