Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899001 | 0.88 | TP53 (0.60) | CXCR2TP53TSHRCXCR1MAPT | |
| SCHEMBL1463448 | 0.86 | MAPT (0.71) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL6760907 | 0.85 | DDX3X (0.59) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL6765010 | 0.85 | MEN1 (0.60) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL6763521 | 0.85 | FADS1 (0.64) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL6760893 | 0.85 | ALDH1A1 (0.60) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL6763526 | 0.85 | MAPT (0.77) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL4356025 | 0.85 | TRPV1 (0.70) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL7594786 | 0.84 | HDAC3 (0.61) | TP53TSHRMAPTRAB9ANPC1 | |
| SCHEMBL6767742 | 0.84 | MAPT (0.64) | TP53TSHRMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063742-A1 | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity | NEUROSEARCH A/S (DK) | 2004-04-01 | — | — | US | claimed |
| US-20040063742-A1 | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity | NEUROSEARCH A/S (DK) | 2004-04-01 | — | — | US | disclosed |