Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 2/20 | 0.64 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6760901 | 0.90 | EPHX2 (0.56) | P2RX1TMPRSS4MAPTCA12CA1 | |
| SCHEMBL1463349 | 0.89 | GSK3A (0.66) | GSK3AGSK3BMAPTAKR1C3MEN1 | |
| SCHEMBL6763103 | 0.84 | CYP3A4 (0.61) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6763008 | 0.80 | CXCR2 (0.67) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL6765116 | 0.80 | LPAR1 (0.60) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL1462402 | 0.79 | NTRK1 (0.69) | GSK3AGSK3BMAPTAKR1C3MEN1 | |
| SCHEMBL130066 | 0.78 | TMPRSS4 (1.00) | P2RX1TMPRSS4AKR1C3MEN1KMT2A | |
| SCHEMBL1463448 | 0.77 | MAPT (0.71) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL1463485 | 0.77 | AKR1C3 (0.70) | GSK3AGSK3BMAPTAKR1C3MEN1 | |
| SCHEMBL6763526 | 0.77 | MAPT (0.77) | MAPTMEN1KMT2AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063742-A1 | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity | NEUROSEARCH A/S (DK) | 2004-04-01 | — | — | US | claimed |
| US-20040063742-A1 | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity | NEUROSEARCH A/S (DK) | 2004-04-01 | — | — | US | disclosed |