SCHEMBL676342

SCHEMBL676342

O=c1c(-c2ccccc2)c(O)oc2cc(O)c(O)c(O)c12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.58
ABCB1 P08183 6/20 0.58
MEN1 O00255 5/20 0.58
CYP3A4 P08684 4/20 0.58
MAPT P10636 4/20 0.58
PTPRS Q13332 4/20 0.58
CYP1A1 P04798 3/20 0.58
CYP1B1 Q16678 3/20 0.58
FTO Q9C0B1 3/20 0.58
KDM4E B2RXH2 3/20 0.58
HPGD P15428 3/20 0.58
ALOX15 P16050 3/20 0.58
HSD17B10 Q99714 3/20 0.58
CYP1A2 P05177 2/20 0.58
CYP2D6 P10635 2/20 0.58
CYP2C9 P11712 2/20 0.58
CYP2C19 P33261 2/20 0.58
XDH P47989 2/20 0.58
GABRP O00591 2/20 0.58
GABRD O14764 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL738107 0.87 MEN1 (0.70) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL1255490 0.84 MEN1 (0.48) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL27322035 0.84 FLT3 (0.64) KMT2AABCB1MEN1MAPTPTPRS
SCHEMBL27961372 0.82 ABCB1 (0.52) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL20815507 0.82 ABCB1 (0.51) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL157972 0.80 MAPK8 (0.74) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL31344371 0.80 MEN1 (0.62) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL1607111 0.80 MEN1 (0.62) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL28278290 0.79 ALDH1A1 (0.60) KMT2AABCB1MEN1CYP3A4MAPT
SCHEMBL27454803 0.79 CREB1 (0.55) KMT2AABCB1MEN1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111574490-A Synthesis method of polyhydroxy isoflavone 中国人民解放军联勤保障部队第九〇四医院 2020-08-25 CN claimed
CN-111560000-A Synthesis method of polyhydroxy isoflavone 中国人民解放军联勤保障部队第九〇四医院 2020-08-21 CN claimed
US-20190142940-A1 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2019-05-16 US claimed
CN-103087027-B Preparation process of polyhydroxy isoflavone COLLEGE OF MILITARY PREVENTIVE MEDICINE THIRD MILITARY MEDICAL UNIVERSITY OF PLA 2014-11-19 CN claimed
CN-103087027-A Preparation process of polyhydroxy isoflavone MILITARY PREVENTION MEDICAL COLLEGE THIRD MILITARY MEDICAL UNIVERSITY OF PLA 2013-05-08 CN claimed
CN-102277304-B Aspergillus aculeatus bacterial strain and method for preparing 5,7,8,4'-tetrahydroxyisoflavone by using same UNIV NANJING NORMAL 2013-02-13 CN claimed
US-20120207809-A1 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2012-08-16 US claimed
US-20120076848-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2012-03-29 US claimed
CN-102277304-A Aspergillus aculeatus bacterial strain and method for preparing 5,7,8,4'-tetrahydroxyisoflavone by using same 2011-12-14 CN claimed
US-20110280909-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2011-11-17 US claimed
WO-2011011065-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2011-01-27 WO claimed
EP-2265725-A1 METHOD FOR PREPARING ORTHO-DIHYDROXYISOFLAVONES USING A BIOTRANSFORMATION SYSTEM Amorepacific Corporation (KR) 2010-12-29 EP claimed
WO-2010087983-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2010-08-05 WO claimed
CN-101648937-A Isoflavone compound and preparation and application thereof BASILEA PHARMACEUTICAL CHINA L 2010-02-17 CN claimed
WO-2009131264-A1 METHOD FOR PREPARING ORTHO-DIHYDROXYISOFLAVONES USING A BIOTRANSFORMATION SYSTEM AMOREPACIFIC CORPORATION (KR) 2009-10-29 WO claimed
CN-118028405-A Method for converting genistein into two flavone compounds by one-step biology 南京师范大学 2024-05-14 CN disclosed
CN-117813017-A Method for improving intestinal microbiota diversity 雀巢产品有限公司 2024-04-02 CN disclosed
CN-1089086-C Luminandide medicine MILLS RANDELL L (US) 2002-08-14 CN disclosed
CN-1312712-A Therapeutic composition based on flavonoids for use in treatment of tumours with cytotoxic agents L LAB (FR) 2001-09-12 CN disclosed
CN-1047075-A Luminandide medicine MILLS RANDELL L (US) 1990-11-21 CN disclosed