Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 18/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 16/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 16/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658591 | 0.90 | ADRA1A (0.72) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL5661401 | 0.88 | ADRA1A (0.73) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7096127 | 0.88 | ADRA1A (0.73) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL6764196 | 0.83 | ADRA1A (0.81) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL3986844 | 0.78 | ADRA1A (0.90) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL6712292 | 0.77 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7093785 | 0.77 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL6710975 | 0.77 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7091765 | 0.77 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL5660443 | 0.76 | ADRA1A (0.54) | ADRA1AADRA1DADRA1BMCHR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727264-B1 | MELANIN CONCENTRATING HORMONE-1 RECEPTOR ANTAGONISTS; SLEEP, EATING, SEXUAL DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-27 | — | — | US | disclosed |