Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | CCR5 | P51681 | 3/20 | 0.36 |
| ▸ | CCR8 | P51685 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12786374 | 0.66 | OPRM1 (0.32) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6764220 | 0.66 | LMNA (0.46) | PDE10ACCR1CCR5CCR8MAPT | |
| SCHEMBL4668738 | 0.62 | CHRM2 (0.45) | MAPTLMNAKDM4ESMN1; SMN2TP53 | |
| Iodide SCHEMBL6763887 | 0.62 | LMNA (0.38) | PDE10ACCR1CCR5CCR8MAPT | |
| Phenanthroline SCHEMBL29354015 | 0.60 | CCR1 (1.00) | PDE10ACCR1CCR5CCR8MAPT | |
| Phenanthroline SCHEMBL29367277 | 0.60 | CCR1 (1.00) | PDE10ACCR1CCR5CCR8MAPT | |
| Phenanthroline SCHEMBL8845760 | 0.60 | CCR1 (1.00) | PDE10ACCR1CCR5CCR8MAPT | |
| Phenanthroline SCHEMBL8312 | 0.60 | CCR1 (1.00) | PDE10ACCR1CCR5CCR8MAPT | |
| SCHEMBL7454331 | 0.59 | — | — | |
| SCHEMBL11379744 | 0.58 | LMNA (0.61) | PDE10ACCR1CCR5CCR8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730788-B1 | COUPLING WITH KETONE IN PRESENCE OF LANTHANIDE II METAL COMPOUND | UNIVERSITY OF NOTRE DAME | 2004-05-04 | — | — | US | disclosed |