Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 14/20 | 0.52 |
| ▸ | RORC | P51449 | 6/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.41 |
| ▸ | THRA | P10827 | 9/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769194 | 0.78 | THRB (0.42) | THRBRORC | |
| SCHEMBL7521261 | 0.76 | THRB (0.49) | THRBRORCCSNK2A1THRA | |
| SCHEMBL6775732 | 0.75 | RORC (0.54) | THRBRORCTHRA | |
| SCHEMBL281885 | 0.69 | THRB (0.79) | THRBRORCTHRA | |
| SCHEMBL23663209 | 0.69 | THRB (0.43) | THRBRORCTHRA | |
| SCHEMBL7069261 | 0.68 | THRB (0.77) | THRBRORCTHRA | |
| SCHEMBL282442 | 0.68 | THRB (1.00) | THRBRORCTHRA | |
| SCHEMBL6775887 | 0.67 | THRB (0.36) | THRB | |
| SCHEMBL6943761 | 0.67 | KDM4E (0.48) | CSNK2A1 | |
| SCHEMBL6769171 | 0.66 | THRB (0.31) | THRBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723717-B1 | CARDIAC-SPARING; SIDE EFFECT REDUCTION | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2004-04-20 | — | — | US | disclosed |