Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.54 |
| ▸ | THRB | P10828 | 6/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ESRRA | P11474 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769373 | 0.89 | MTNR1B (0.47) | RORCTHRBMTNR1BMTNR1AALDH1A1 | |
| SCHEMBL22959250 | 0.76 | RORC (0.72) | RORCTHRBTHRA | |
| SCHEMBL6765878 | 0.75 | THRB (0.52) | RORCTHRBTHRA | |
| SCHEMBL6775933 | 0.74 | MTNR1B (0.46) | RORCTHRBMTNR1BMEN1KMT2A | |
| SCHEMBL22959193 | 0.73 | RORC (0.74) | RORCTHRBTHRA | |
| SCHEMBL14886137 | 0.73 | MAPT (0.67) | POLBESRRAMAPTCDYLMEN1 | |
| SCHEMBL22959327 | 0.71 | RORC (0.72) | RORCTHRBALDH1A1THRA | |
| SCHEMBL22959253 | 0.71 | RORC (0.71) | RORCTHRBTHRA | |
| SCHEMBL6765992 | 0.71 | AR (0.52) | THRBMEN1KMT2ATHRA | |
| SCHEMBL22959398 | 0.70 | RORC (0.67) | RORCTHRBMTNR1BTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723717-B1 | CARDIAC-SPARING; SIDE EFFECT REDUCTION | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2004-04-20 | — | — | US | disclosed |