Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.77 |
| ▸ | RORC | P51449 | 11/20 | 0.77 |
| ▸ | THRA | P10827 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281885 | 0.88 | THRB (0.79) | THRBRORCTHRA | |
| SCHEMBL282442 | 0.87 | THRB (1.00) | THRBRORCTHRA | |
| SCHEMBL7071121 | 0.84 | THRB (0.55) | THRBRORCTHRA | |
| SCHEMBL5618863 | 0.84 | RORC (0.72) | THRBRORCTHRA | |
| SCHEMBL7073154 | 0.83 | THRB (0.71) | THRBRORCTHRA | |
| SCHEMBL22959261 | 0.82 | THRB (0.70) | THRBRORCTHRA | |
| SCHEMBL6818059 | 0.82 | RORC (0.70) | THRBRORCTHRA | |
| SCHEMBL7073265 | 0.81 | THRB (0.76) | THRBRORCTHRA | |
| SCHEMBL22959356 | 0.80 | RORC (0.67) | THRBRORCTHRA | |
| SCHEMBL2169907 | 0.79 | RORC (0.65) | THRBRORCTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000008-B1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KAROBIO AB (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-6465687-B1 | SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE | KARO BIO AB (SE) | 2002-10-15 | — | — | US | disclosed |