Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | MASP2 | O00187 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766369 | 0.86 | KCNN4 (0.43) | CASP6GAACASP3SENP8SENP7 | |
| SCHEMBL6772719 | 0.83 | KDM4E (0.41) | GAAALDH1A1LMNAL3MBTL1CYP2D6 | |
| SCHEMBL5781166 | 0.83 | HTR7 (0.46) | DRD2ALDH1A1KDM4EHTR7MAOB | |
| Hydrochloric Acid SCHEMBL5782879 | 0.82 | HTR7 (0.45) | ALDH1A1KDM4EHTR7MAOB | |
| SCHEMBL6766920 | 0.81 | CYP2D6 (0.53) | GAAKMT2AMEN1PTGS2ALDH1A1 | |
| SCHEMBL5777171 | 0.78 | POLB (0.52) | ALDH1A1L3MBTL1CYP2D6KDM4EMAOB | |
| SCHEMBL6763441 | 0.78 | LMNA (0.46) | GAALMNAL3MBTL1KDM4EMAOB | |
| SCHEMBL5780097 | 0.78 | KMT2A (0.37) | KMT2ACYP2D6MAOB | |
| Hydrochloric Acid SCHEMBL5783222 | 0.78 | POLB (0.51) | ALDH1A1L3MBTL1CYP2D6KDM4EMAOB | |
| SCHEMBL10633526 | 0.77 | KMT2A (0.50) | GAAKMT2AMEN1CD274ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |