Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306292 | 0.98 | HTR1A (0.47) | HTR1AHTR1DHTR1BSLC6A4GRIN1 | |
| SCHEMBL8306321 | 0.98 | HTR1A (0.47) | HTR1AHTR1DHTR1BSLC6A4GRIN1 | |
| Oxalic Acid SCHEMBL8153432 | 0.94 | HTR1A (0.44) | HTR1AHTR1DHTR1BSLC6A4SMN1; SMN2 | |
| Oxalic Acid SCHEMBL8157336 | 0.94 | HTR1A (0.44) | HTR1AHTR1DHTR1BSLC6A4SMN1; SMN2 | |
| SCHEMBL8142921 | 0.94 | HTR1A (0.49) | HTR1AHTR1DHTR1BSLC6A4SMN1; SMN2 | |
| SCHEMBL8156185 | 0.86 | SIGMAR1 (0.35) | GRIN1GRIN2B | |
| SCHEMBL8305321 | 0.86 | ADRA1B (0.38) | HTR1AHTR1DHTR1BSLC6A4ADRA1B | |
| Oxalic Acid SCHEMBL8148211 | 0.82 | FFAR4 (0.38) | HTR1AHTR1DHTR1BSLC6A4ADRA1B | |
| SCHEMBL8149460 | 0.81 | PARP1 (0.36) | HTR1AGRIN1GRIN2B | |
| SCHEMBL8148403 | 0.80 | HTR1A (0.57) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673375-B1 | FUSED BENZO COMPOUNDS | LUNDBECK & CO AS H (DK) | 1999-02-24 | — | — | EP | claimed |
| US-20040023948-A1 | Fast-dispersing dosage form containing 5-HT1 agonists | CATALENT USA PAINTBALL, INC. | 2004-02-05 | — | — | US | disclosed |
| US-6140331-A | FOR TREATING ANXIETY DISORDERS, DEPRESSION, PSYCHOSIS, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, ISCHAEMIC DISEASES, CARDIOVASCULAR DISORDERS, SIDE EFFECTS INDUCED BY CONVENTIONAL ANTIPSYCHOTIC AGENTS AND SENILE DEMENTIA | H. LUNDBECK A/S (DK) | 2000-10-31 | — | — | US | disclosed |
| EP-0673375-B1 | FUSED BENZO COMPOUNDS | LUNDBECK & CO AS H (DK) | 1999-02-24 | — | — | EP | disclosed |
| EP-0673375-A1 | FUSED BENZO COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013659-A1 | FUSED BENZO COMPOUNDS | H. LUNDBECK A/S (DK) | 1994-06-23 | — | — | WO | disclosed |