Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 7/20 | 0.39 |
| ▸ | NOS1 | P29475 | 5/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329387 | 0.85 | NOS2 (0.55) | NOS2NOS1NOS3 | |
| SCHEMBL8326237 | 0.81 | NOS2 (0.41) | NOS2NOS1NOS3PDE10A | |
| SCHEMBL8329711 | 0.81 | NOS2 (0.41) | NOS2NOS1NOS3PDE10A | |
| SCHEMBL8326231 | 0.81 | NOS2 (0.41) | NOS2NOS1NOS3PDE10A | |
| SCHEMBL8328239 | 0.80 | NOS1 (0.37) | NOS2NOS1NOS3PDE10A | |
| SCHEMBL8328137 | 0.80 | NOS2 (0.51) | NOS2NOS1NOS3 | |
| SCHEMBL13040598 | 0.79 | NOS2 (0.37) | NOS2NOS1NOS3 | |
| SCHEMBL13040665 | 0.78 | NOS2 (0.42) | NOS2NOS1NOS3 | |
| SCHEMBL2834751 | 0.78 | NOS1 (0.44) | NOS2NOS1NOS3 | |
| SCHEMBL5672155 | 0.78 | NOS2 (0.36) | NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762176-B1 | INHIBITING NO-SYNTHASE ENZYMES PRODUCING NITROGEN MONOXIDE AND/OR TRAPPING REACTIVE FORMS OF OXYGEN; INHIBIT LIPIDIC PEROXIDATION | SOCIETE DE CONSELLS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-07-13 | — | — | US | disclosed |
| US-6727239-B1 | INHIBITORY ACTIVITY ON NO- SYNTHASE ENZYMES PRODUCING NITROGEN MONOXIDE NO AND/OR AN ACTIVITY WHICH TRAPS THE REACTIVE OXYGEN SPECIES (ROS) | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-27 | — | — | US | disclosed |
| EP-1095020-A1 | 2-AMINOPYRIDINE ERIVATIVES, THEIR USE AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002860-A1 | 2-AMINOPYRIDINE ERIVATIVES, THEIR USE AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-01-20 | — | — | WO | disclosed |