Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | MYC | P01106 | 5/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329387 | 0.82 | NOS2 (0.55) | NOS1NOS2NOS3ESR1 | |
| SCHEMBL6767585 | 0.81 | RXRA (0.50) | NOS1NOS2NOS3KDM4ERXRA | |
| SCHEMBL6766749 | 0.80 | NOS2 (0.39) | NOS1NOS2NOS3PDE10A | |
| SCHEMBL6762802 | 0.80 | CTSB (0.45) | MYCNR4A1PTPN7HSD17B10KDM4E | |
| SCHEMBL6164330 | 0.80 | RXRA (0.46) | NOS1NOS2NOS3KDM4EMAPT | |
| SCHEMBL5672155 | 0.79 | NOS2 (0.36) | NOS1NOS2NOS3 | |
| SCHEMBL8326231 | 0.79 | NOS2 (0.41) | NOS1NOS2NOS3PDE10A | |
| SCHEMBL8329711 | 0.79 | NOS2 (0.41) | NOS1NOS2NOS3PDE10A | |
| SCHEMBL8326237 | 0.79 | NOS2 (0.41) | NOS1NOS2NOS3PDE10A | |
| SCHEMBL6765287 | 0.78 | NOS2 (0.38) | NOS1NOS2NOS3RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |