Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763399 | 0.81 | HTR7 (0.35) | PDCD1CD274KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL5778171 | 0.81 | MEN1 (0.39) | PDCD1CD274KDM4EMEN1KMT2A | |
| SCHEMBL5780049 | 0.81 | SLC5A2 (0.36) | PDCD1CD274KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6767423 | 0.79 | GRIA1 (0.37) | KDM4EMEN1KMT2AHTTPKM | |
| SCHEMBL5778501 | 0.78 | MAPT (0.42) | PDCD1CD274KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6767437 | 0.78 | MAPK14 (0.36) | KDM4ESMN1; SMN2KMT2ALMNAPOLB | |
| Hydrochloric Acid SCHEMBL5780693 | 0.77 | MAPT (0.41) | PDCD1CD274KDM4ESMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL6765921 | 0.77 | MAPK14 (0.35) | KDM4ESMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL6766369 | 0.74 | KCNN4 (0.43) | PDCD1CD274SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6766055 | 0.74 | CASP6 (0.41) | PDCD1CD274KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |