SCHEMBL6767694

SCHEMBL6767694

CN1CCCC1CCOc1cccnc1C1=NN(c2ccccc2)C(=O)CO1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 3/20 0.41
CHRNA3 P32297 3/20 0.41
CHRNB1 P11230 1/20 0.41
CHRNB2 P17787 1/20 0.41
CHRNA4 P43681 1/20 0.41
CHRNB3 Q05901 1/20 0.41
PIK3CD O00329 1/20 0.38
HRH3 Q9Y5N1 2/20 0.37
SLC22A1 O15245 1/20 0.37
MLNR O43193 1/20 0.37
NR1I2 O75469 1/20 0.37
TP53 P04637 1/20 0.37
ADRB2 P07550 1/20 0.37
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
ADRB1 P08588 1/20 0.37
CYP3A4 P08684 1/20 0.37
HTR1A P08908 1/20 0.37
CHRM5 P08912 1/20 0.37
ADRA2A P08913 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6768118 0.99 CHRNB4 (0.41) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL6768461 0.83 TDP1 (0.41) CYP2D6DRD2TSHRDRD1HTR2A
SCHEMBL6763407 0.82 TSHR (0.42) CYP2D6DRD2TSHRDRD1HTR2A
Hydrochloric Acid SCHEMBL6766915 0.82 TDP1 (0.40) CYP2D6DRD2TSHRDRD1HTR2A
Hydrochloric Acid SCHEMBL6766958 0.81 TSHR (0.41) CYP2D6DRD2TSHRDRD1HTR2A
SCHEMBL6763485 0.81 CYP11B1 (0.36) CHRM2CYP3A4CHRM1TSHRDRD3
SCHEMBL5781776 0.80 HTR7 (0.38) CHRM2CYP3A4CHRM1DRD2TSHR
SCHEMBL5779879 0.80 POLB (0.45) DRD1
Hydrochloric Acid SCHEMBL5780676 0.79 HTR7 (0.37) DRD2DRD1HRH1
Hydrochloric Acid SCHEMBL5777092 0.79 POLB (0.44) DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1153922-A1 HETERODIAZINONE DERIVATIVES Eisai Co., Ltd. (JP) 2001-11-14 EP claimed
US-6825192-B1 NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION EISAI CO., LTD. (JP) 2004-11-30 US disclosed
EP-1153922-A1 HETERODIAZINONE DERIVATIVES Eisai Co., Ltd. (JP) 2001-11-14 EP disclosed