Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6766958 | 0.99 | TSHR (0.41) | TSHRKDM4ESMN1; SMN2HRH1DRD1 | |
| SCHEMBL6768461 | 0.99 | TDP1 (0.41) | TSHRKDM4ESMN1; SMN2HRH1DRD1 | |
| Hydrochloric Acid SCHEMBL6766915 | 0.98 | TDP1 (0.40) | TSHRKDM4ESMN1; SMN2HRH1DRD1 | |
| SCHEMBL5779879 | 0.91 | POLB (0.45) | KDM4ESMN1; SMN2DRD1DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL5777092 | 0.90 | POLB (0.44) | KDM4EDRD1DRD4DRD5MEN1 | |
| SCHEMBL6763508 | 0.87 | KDM4E (0.52) | TSHRKDM4ESMN1; SMN2HRH1DRD1 | |
| SCHEMBL6763534 | 0.86 | KDM4E (0.50) | TSHRKDM4ESMN1; SMN2HRH1DRD1 | |
| SCHEMBL6763485 | 0.85 | CYP11B1 (0.36) | TSHRKDM4ESMN1; SMN2DRD3TDP1 | |
| SCHEMBL6767694 | 0.82 | CHRNB4 (0.41) | TSHRHRH1DRD1DRD3DRD2 | |
| SCHEMBL5781776 | 0.82 | HTR7 (0.38) | TSHRKDM4ESMN1; SMN2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |