Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781776 | 0.86 | HTR7 (0.38) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL5780676 | 0.85 | HTR7 (0.37) | KDM4EALDH1A1PTGS1PTGS2SHMT2 | |
| SCHEMBL6768461 | 0.85 | TDP1 (0.41) | KDM4EMEN1KMT2AHSD17B10GAA | |
| SCHEMBL6763407 | 0.85 | TSHR (0.42) | KDM4EMEN1KMT2AHSD17B10GAA | |
| Hydrochloric Acid SCHEMBL6766915 | 0.85 | TDP1 (0.40) | KDM4EMEN1KMT2AHSD17B10GAA | |
| SCHEMBL5778908 | 0.84 | PTGS1 (0.46) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6766958 | 0.84 | TSHR (0.41) | KDM4EMEN1KMT2AHSD17B10GAA | |
| SCHEMBL5779879 | 0.84 | POLB (0.45) | KDM4EMEN1KMT2AALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL5777092 | 0.83 | POLB (0.44) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL6767694 | 0.81 | CHRNB4 (0.41) | CHRM2CYP3A4CHRM1TSHRDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |