Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.52 |
| ▸ | GRK2 | P25098 | 2/20 | 0.52 |
| ▸ | GRK5 | P34947 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766170 | 0.93 | KDR (0.46) | ROCK1GRK2GRK5ROCK2SYK | |
| SCHEMBL7077576 | 0.87 | ROCK1 (0.55) | ROCK1GRK2GRK5PTK2PTK2B | |
| SCHEMBL6770452 | 0.86 | RPS6KB1 (0.51) | ROCK1ROCK2SYKJAK2IRAK4 | |
| SCHEMBL6769928 | 0.84 | RPS6KB1 (0.52) | ROCK1ROCK2SYKMAPK1EGFR | |
| SCHEMBL6611762 | 0.84 | SYK (0.49) | ROCK1ROCK2SYKJAK2MAPK1 | |
| SCHEMBL6766687 | 0.84 | RPS6KB1 (0.53) | ROCK1ROCK2SYKMAPK1EGFR | |
| SCHEMBL6769085 | 0.81 | SYK (0.52) | ROCK1ROCK2SYKJAK2IRAK4 | |
| SCHEMBL6769930 | 0.81 | LMNA (0.47) | ROCK1ROCK2SYKJAK2IRAK4 | |
| SCHEMBL6769445 | 0.80 | HSD17B10 (0.46) | EGFRERBB2NPC1SMN1; SMN2HTT | |
| SCHEMBL6639550 | 0.79 | SYK (0.53) | ROCK1ROCK2SYKJAK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | disclosed |