Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CLK2 | P49760 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771569 | 0.93 | LMNA (0.47) | LMNAROCK2ROCK1THRBJAK3 | |
| SCHEMBL7081412 | 0.86 | ALDH1A1 (0.48) | LMNAROCK2ROCK1JAK3IRAK4 | |
| SCHEMBL6611762 | 0.85 | SYK (0.49) | LMNAROCK2ROCK1MAPTSYK | |
| SCHEMBL6769085 | 0.84 | SYK (0.52) | ROCK2ROCK1IRAK4SYKHTT | |
| SCHEMBL6770452 | 0.83 | RPS6KB1 (0.51) | LMNAROCK2ROCK1JAK3IRAK4 | |
| SCHEMBL6769928 | 0.81 | RPS6KB1 (0.52) | LMNAROCK2ROCK1MAPTALDH1A1 | |
| SCHEMBL6766687 | 0.81 | RPS6KB1 (0.53) | ROCK2ROCK1SYKHTTCDK2 | |
| SCHEMBL6769259 | 0.81 | ROCK1 (0.52) | ROCK2ROCK1JAK3IRAK4ALDH1A1 | |
| SCHEMBL6639550 | 0.80 | SYK (0.53) | ROCK2ROCK1JAK3IRAK4SYK | |
| SCHEMBL7077388 | 0.79 | ALDH1A1 (0.48) | LMNAALDH1A1METTL3HTTCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | disclosed |