Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 1.00 |
| ▸ | RAB9A | P51151 | 9/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 1.00 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | NCS1 | P62166 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13568288 | 0.90 | NPC1 (0.82) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL4920242 | 0.87 | RAB9A (0.79) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL6769684 | 0.87 | NPC1 (1.00) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL4916732 | 0.86 | NPC1 (0.74) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL1353347 | 0.84 | KDM4E (0.74) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL5740431 | 0.83 | RAB9A (0.70) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL30553297 | 0.82 | RAB9A (0.70) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL16549373 | 0.82 | KDM4E (0.70) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL31119660 | 0.82 | NPC1 (0.69) | NPC1RAB9AL3MBTL1PKMPAX8 | |
| SCHEMBL1353349 | 0.81 | KDM4E (0.81) | NPC1RAB9AL3MBTL1PKMPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720344-B2 | BINDING TO NUCLEAR RECEPTOR PROTEINS; STIMULATING BMP-2 PROMOTER ACTIVITY | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2004-04-13 | — | — | US | claimed |
| US-20030119791-A1 | Methods and compositions for stimulating osteoblast proliferation or treating malignant cell proliferation and methods for selecting osteoblast proliferation stimulants | KERWIN SEAN M (US) | 2003-06-26 | — | — | US | claimed |
| EP-0912549-A4 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | UNIV TEXAS (US) | 2002-01-02 | — | — | EP | claimed |
| JP-2000514048-A | — | — | 2000-10-24 | — | — | JP | claimed |
| CN-1226245-A | Compound with pharmacological activity, preparation method and application thereof | UNIV TEXAS (US) | 1999-08-18 | — | — | CN | claimed |
| EP-0912549-A1 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-05-06 | — | — | EP | claimed |
| WO-1997048694-A1 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-12-24 | — | — | WO | claimed |
| US-20250213601-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES | Didenko, Kirill (US) | 2025-07-03 | — | — | US | disclosed |
| WO-2023187599-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES | DIDENKO KIRILL (MX) | 2023-10-05 | — | — | WO | disclosed |
| US-20130150399-A1 | INHIBITORS OF THE UNFOLDED PROTEIN RESPONSE AND METHODS FOR THEIR USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-06-13 | — | — | US | disclosed |
| US-8372861-B2 | Inhibitors of the unfolded protein response and methods for their use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-02-12 | — | — | US | disclosed |
| US-20090312362-A1 | INHIBITORS OF THE UNFOLDED PROTEIN RESPONSE AND METHODS FOR THEIR USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2009-12-17 | — | — | US | disclosed |
| US-6720344-B2 | BINDING TO NUCLEAR RECEPTOR PROTEINS; STIMULATING BMP-2 PROMOTER ACTIVITY | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2004-04-13 | — | — | US | disclosed |
| US-20030119791-A1 | Methods and compositions for stimulating osteoblast proliferation or treating malignant cell proliferation and methods for selecting osteoblast proliferation stimulants | KERWIN SEAN M (US) | 2003-06-26 | — | — | US | disclosed |
| EP-0912549-A4 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | UNIV TEXAS (US) | 2002-01-02 | — | — | EP | disclosed |
| CN-1226245-A | Compound with pharmacological activity, preparation method and application thereof | UNIV TEXAS (US) | 1999-08-18 | — | — | CN | disclosed |
| EP-0912549-A1 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997048694-A1 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312362-A1 | INHIBITORS OF THE UNFOLDED PROTEIN RESPONSE AND METHODS FOR THEIR USE | XBP1, HSPA5, RNASE1 | NPC1 2719/4885RAB9A 3339/4885L3MBTL1 1596/4885 |
| US-20030119791-A1 | Methods and compositions for stimulating osteoblast proliferation or treating malignant cell proliferation and methods for selecting osteoblast proliferation stimulants | MKI67, HGF, AREG | NPC1 3040/4885RAB9A 4564/4885L3MBTL1 4879/4885 |
| US-20250213601-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES | ACE2, FURIN, SARS1 | NPC1 23/4885RAB9A 1443/4885L3MBTL1 1330/4885 |
| US-20130150399-A1 | INHIBITORS OF THE UNFOLDED PROTEIN RESPONSE AND METHODS FOR THEIR USE | XBP1, HSPA5, RNASE1 | NPC1 2719/4885RAB9A 3339/4885L3MBTL1 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.