Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.67 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770366 | 0.85 | SRC (0.56) | OPRM1SRCKMT2AALDH1A1KDM4E | |
| SCHEMBL6772487 | 0.85 | SRC (0.53) | OPRM1SRCMAPK1KMT2AHPGD | |
| SCHEMBL6769466 | 0.85 | SRC (0.53) | OPRM1SRCMAPK1KMT2AHPGD | |
| SCHEMBL6162529 | 0.84 | OPRM1 (0.56) | OPRM1SRCKMT2AHPGDALDH1A1 | |
| SCHEMBL6771814 | 0.83 | SRC (0.60) | OPRM1SRCMAPK1KMT2AHPGD | |
| SCHEMBL6771081 | 0.83 | ALDH1A1 (0.58) | OPRM1SRCMAPK1KMT2AHPGD | |
| SCHEMBL6770710 | 0.82 | SRC (0.50) | OPRM1SRCMAPK1KMT2AHPGD | |
| SCHEMBL6771820 | 0.81 | OPRM1 (0.75) | OPRM1SRCOPRD1OPRK1 | |
| SCHEMBL6777711 | 0.81 | OPRM1 (0.45) | OPRM1SRCMAPK1KMT2AHPGD | |
| SCHEMBL6769819 | 0.78 | OPRM1 (0.43) | OPRM1SRCMAPK1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |