Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776683 | 0.87 | LMNA (0.46) | SRCLMNATSHRHTTALDH1A1 | |
| SCHEMBL6165127 | 0.87 | ALDH1A1 (0.43) | SRCLMNATSHRHTTALDH1A1 | |
| SCHEMBL6769419 | 0.87 | SRC (0.47) | SRCLMNATSHRHTTALDH1A1 | |
| SCHEMBL6771081 | 0.85 | ALDH1A1 (0.58) | SRCLMNATSHRHTTALDH1A1 | |
| SCHEMBL6769466 | 0.82 | SRC (0.53) | SRCLMNATSHRHTTALDH1A1 | |
| SCHEMBL6770491 | 0.82 | OPRM1 (0.51) | SRCLMNAALDH1A1OPRM1KMT2A | |
| SCHEMBL6769517 | 0.82 | SRC (0.39) | SRCLMNAALDH1A1KDM4ETP53 | |
| SCHEMBL6769828 | 0.82 | OPRM1 (0.67) | SRCLMNATSHRHTTALDH1A1 | |
| SCHEMBL6772419 | 0.81 | SRC (0.39) | SRCLMNAALDH1A1KDM4ETP53 | |
| SCHEMBL6767118 | 0.80 | HTT (0.40) | SRCLMNATSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |