Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765350 | 0.87 | CCR2 (0.63) | CCR2CYP2D6LMNACHRM2HTR1A | |
| SCHEMBL6770834 | 0.85 | CCR2 (0.49) | CCR2CYP2D6LMNACHRM2HTR1A | |
| SCHEMBL7986044 | 0.75 | SIGMAR1 (0.55) | CHRM2CHRM1KCNH2MEN1KMT2A | |
| SCHEMBL6765644 | 0.74 | CHRM2 (0.60) | CCR2CYP2D6LMNACHRM2HTR1A | |
| SCHEMBL7989733 | 0.73 | SIGMAR1 (0.64) | HTR1AOPRM1 | |
| SCHEMBL30812113 | 0.73 | EPHX2 (0.60) | LMNACHRM2CHRM1MAPK1MEN1 | |
| SCHEMBL6768912 | 0.73 | KMT2A (0.59) | LMNACHRM2HTR1ACHRM1MEN1 | |
| SCHEMBL8210703 | 0.73 | KMT2A (0.55) | LMNACHRM2CHRM1MEN1KMT2A | |
| SCHEMBL31245991 | 0.73 | EPHX2 (0.59) | LMNACHRM2CHRM1MAPK1 | |
| SCHEMBL30812306 | 0.73 | SIGMAR1 (0.54) | CHRM2CHRM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686353-B1 | PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE | TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-0914319-B1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A9 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | — | 1998-03-12 | — | — | WO | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |