Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971782 | 0.95 | SIGMAR1 (0.69) | SIGMAR1HTR2AOPRM1ADORA3HTR7 | |
| SCHEMBL8526553 | 0.94 | SIGMAR1 (0.59) | SIGMAR1CHRM3HTR2AOPRM1ADORA3 | |
| SCHEMBL7986044 | 0.93 | SIGMAR1 (0.55) | SIGMAR1CHRM3ACKR3 | |
| SCHEMBL3712707 | 0.87 | MEN1 (0.59) | SIGMAR1CHRM3ACKR3 | |
| SCHEMBL7985885 | 0.85 | SIGMAR1 (0.59) | SIGMAR1CHRM3FAAH | |
| SCHEMBL8210703 | 0.85 | KMT2A (0.55) | CHRM3 | |
| SCHEMBL7983371 | 0.85 | GPR119 (0.61) | SIGMAR1 | |
| SCHEMBL31752794 | 0.84 | SIGMAR1 (0.56) | SIGMAR1HTR2AOPRM1ADORA3HTR7 | |
| SCHEMBL7985879 | 0.84 | SIGMAR1 (0.92) | SIGMAR1CHRM3FAAH | |
| SCHEMBL1421344 | 0.83 | SIGMAR1 (0.55) | SIGMAR1CHRM3HTR2AOPRM1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |