Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 10/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771220 | 0.88 | MAPT (0.33) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6769771 | 0.88 | MAPT (0.37) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6776532 | 0.79 | SRC (0.36) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6770073 | 0.76 | MAPT (0.34) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6771854 | 0.76 | MAPT (0.33) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7545320 | 0.70 | MAPT (0.36) | MAPTPIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL6770582 | 0.67 | PDE4A (0.34) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6770673 | 0.65 | CACNA2D1 (0.32) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7479730 | 0.64 | OPRM1 (0.54) | — | |
| SCHEMBL7536258 | 0.61 | MAPT (0.39) | MAPTDHODHL3MBTL1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |