Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538552 | 0.80 | SRC (0.42) | MAPTL3MBTL1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7539099 | 0.78 | ALDH1A1 (0.40) | MAPTALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL7536258 | 0.77 | MAPT (0.39) | MAPTDHODHL3MBTL1MGLLALDH1A1 | |
| SCHEMBL6771401 | 0.70 | MAPT (0.36) | MAPTDHODHL3MBTL1KCNH2PIK3CD | |
| SCHEMBL6767135 | 0.67 | OPRM1 (0.41) | DHODHL3MBTL1MGLLALDH1A1LMNA | |
| SCHEMBL6767785 | 0.67 | L3MBTL1 (0.39) | MAPTDHODHL3MBTL1MGLLALDH1A1 | |
| SCHEMBL6771220 | 0.66 | MAPT (0.33) | MAPTDHODHPIK3CDPIK3R2PIK3CA | |
| SCHEMBL6769518 | 0.65 | L3MBTL1 (0.49) | MAPTDHODHL3MBTL1MGLLALDH1A1 | |
| SCHEMBL6776532 | 0.63 | SRC (0.36) | MAPTDHODHL3MBTL1PIK3CDPIK3R2 | |
| SCHEMBL6767006 | 0.62 | OPRM1 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |