Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769771 | 0.69 | MAPT (0.37) | MAPTLMNAL3MBTL1ALDH1A1PKM | |
| SCHEMBL6771990 | 0.69 | OPRM1 (0.54) | MAPTLMNATDP1NPSR1ALDH1A1 | |
| SCHEMBL6771511 | 0.68 | L3MBTL1 (0.49) | MAPTLMNATDP1NPSR1L3MBTL1 | |
| SCHEMBL25762306 | 0.65 | LMNA (0.47) | MAPTLMNATDP1NPSR1L3MBTL1 | |
| SCHEMBL6770476 | 0.65 | OPRM1 (0.45) | MAPTLMNATDP1NPSR1L3MBTL1 | |
| SCHEMBL6770960 | 0.65 | SRC (0.43) | MAPTLMNAL3MBTL1ALDH1A1PKM | |
| SCHEMBL6771854 | 0.65 | MAPT (0.33) | MAPTL3MBTL1DHODH | |
| SCHEMBL6776532 | 0.64 | SRC (0.36) | MAPTLMNANPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL6770401 | 0.63 | OPRM1 (0.77) | LMNANPSR1ALDH1A1OPRM1 | |
| SCHEMBL22924459 | 0.63 | LMNA (0.54) | MAPTLMNATDP1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |