Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16897249 | 0.84 | TDP1 (0.61) | TDP1ALDH1A1LMNACES2CES1 | |
| SCHEMBL15971711 | 0.80 | TSHR (0.55) | ALDH1A1CES2CES1SMN1; SMN2MAPT | |
| SCHEMBL16897300 | 0.78 | CES2 (0.50) | CES2CES1SMN1; SMN2MAPTPKM | |
| SCHEMBL28628636 | 0.78 | LMNA (0.52) | TDP1ALDH1A1LMNAMAPTPKM | |
| SCHEMBL11228311 | 0.77 | LMNA (0.58) | TDP1ALDH1A1LMNACES2CES1 | |
| SCHEMBL248492 | 0.77 | TDP1 (0.70) | TDP1ALDH1A1LMNACES2CES1 | |
| SCHEMBL6654554 | 0.77 | TDP1 (0.70) | TDP1ALDH1A1LMNACES2CES1 | |
| SCHEMBL64626 | 0.77 | TDP1 (0.70) | TDP1ALDH1A1LMNACES2CES1 | |
| SCHEMBL9860907 | 0.76 | LMNA (0.56) | TDP1ALDH1A1LMNACES2CES1 | |
| Ammonia Solution, Strong SCHEMBL8998037 | 0.76 | LMNA (0.56) | TDP1ALDH1A1LMNACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944750-B2 | Polyethylene glycol substituted acyl borates | ETH ZURICH (CH) | 2018-04-17 | — | — | US | disclosed |
| EP-3092263-B1 | POLYETHYLENE GLYCOL SUBSTITUTED ACYL BORATES | ETH ZUERICH (CH) | 2018-02-21 | — | — | EP | disclosed |
| US-20170022321-A1 | POLYETHYLENE GLYCOL SUBSTITUTED ACYL BORATES | ETH ZURICH (CH) | 2017-01-26 | — | — | US | disclosed |
| EP-3092263-A1 | POLYETHYLENE GLYCOL SUBSTITUTED ACYL BORATES | ETH Zurich (CH) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015104374-A1 | POLYETHYLENE GLYCOL SUBSTITUTED ACYL BORATES | ETH ZURICH (CH) | 2015-07-16 | — | — | WO | disclosed |
| US-8283401-B2 | Conjugated diene polymer manufacturing method, polybutadiene, and rubber composition utilizing the same | UBE INDUSTRIES, LTD (JP) | 2012-10-09 | — | — | US | disclosed |
| US-20110269899-A1 | CONJUGATED DIENE POLYMER MANUFACTURING METHOD, POLYBUTADIENE, AND RUBBER COMPOSITION UTILIZING THE SAME | UBE INDUSTRIES, LTD. (JP) | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022321-A1 | POLYETHYLENE GLYCOL SUBSTITUTED ACYL BORATES | BRS3, FFAR3, LPAR3 | TDP1 4349/4885ALDH1A1 3912/4885LMNA 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.