Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.38 |
| ▸ | YWHAH | Q04917 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689186 | 0.90 | PLA2G2A (0.46) | PLA2G2A | |
| SCHEMBL6892310 | 0.90 | FAAH (0.41) | YWHAHFFAR1PTGESFAAHALDH1A1 | |
| SCHEMBL6776978 | 0.88 | PLA2G2A (0.42) | PLA2G2AFAAHSIRT2SIRT1KDM4E | |
| SCHEMBL6774350 | 0.88 | PLA2G2A (0.40) | PLA2G2A | |
| SCHEMBL6775435 | 0.88 | PLA2G2A (0.40) | PLA2G2AFAAHSIRT2SIRT1KDM4E | |
| SCHEMBL6780031 | 0.88 | PLA2G2A (0.44) | PLA2G2A | |
| SCHEMBL6696960 | 0.87 | PLA2G2A (0.47) | PLA2G2AFAAHSIRT2SIRT1KDM4E | |
| SCHEMBL7954113 | 0.87 | PLA2G2A (0.45) | PLA2G2AFFAR1 | |
| SCHEMBL6778086 | 0.87 | F10 (0.40) | PLA2G2A | |
| SCHEMBL6770280 | 0.87 | PLA2G2A (0.40) | PLA2G2APTGESFAAHSIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |