Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.41 |
| ▸ | YWHAH | Q04917 | 4/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694748 | 0.92 | MAPT (0.43) | YWHAHMAPTTHRBALDH1A1 | |
| SCHEMBL6771968 | 0.90 | PLA2G2A (0.38) | FAAHYWHAHFFAR1PTGESALDH1A1 | |
| SCHEMBL6890656 | 0.89 | THRB (0.37) | YWHAHMAPTTHRBALDH1A1 | |
| SCHEMBL6894722 | 0.89 | PLA2G2A (0.41) | FAAHYWHAHMAPTTHRBALDH1A1 | |
| SCHEMBL6896777 | 0.89 | FAAH (0.44) | FAAHTP53MAPTTHRBALDH1A1 | |
| SCHEMBL6691213 | 0.89 | FAAH (0.46) | FAAHTP53MAPTTHRBALDH1A1 | |
| SCHEMBL6896220 | 0.88 | FAAH (0.43) | FAAHTP53MAPTTHRBALDH1A1 | |
| SCHEMBL6893995 | 0.88 | SLC6A2 (0.38) | THRBALDH1A1 | |
| SCHEMBL6894773 | 0.88 | FAAH (0.43) | FAAHTP53MAPTTHRBALDH1A1 | |
| SCHEMBL6899176 | 0.87 | TSPO (0.41) | YWHAHMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |