Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | ICMT | O60725 | 2/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689186 | 0.90 | PLA2G2A (0.46) | PLA2G10PLA2G2APPARG | |
| SCHEMBL6893995 | 0.88 | SLC6A2 (0.38) | F10THRATHRB | |
| SCHEMBL6782681 | 0.88 | ICMT (0.41) | F10CTRB1CCR2THRATHRB | |
| SCHEMBL6770697 | 0.87 | F10 (0.46) | F10CTRB1CCR2PLA2G10ICMT | |
| SCHEMBL6780031 | 0.87 | PLA2G2A (0.44) | F10PLA2G10PLA2G2APPARGKLK1 | |
| SCHEMBL6774350 | 0.87 | PLA2G2A (0.40) | F10THRATHRBPLA2G10PLA2G2A | |
| SCHEMBL6775864 | 0.87 | ADRA1D (0.41) | F10THRATHRBPLA2G2A | |
| SCHEMBL6777431 | 0.87 | PARP1 (0.41) | F10CTRB1CCR2PLA2G10ICMT | |
| SCHEMBL6771968 | 0.87 | PLA2G2A (0.38) | PLA2G2A | |
| SCHEMBL6775770 | 0.86 | F10 (0.39) | F10PLA2G2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |