Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775141 | 0.92 | TLR7 (0.51) | TLR7TLR8NUDT1 | |
| SCHEMBL6778763 | 0.88 | ALDH1A1 (0.42) | TLR7TLR8SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6778839 | 0.87 | MAPKAPK2 (0.43) | TLR7TLR8SMN1; SMN2MAPKAPK2CYP1A2 | |
| SCHEMBL6768640 | 0.83 | TLR7 (0.43) | TLR7TLR8MEN1KMT2ARAB9A | |
| SCHEMBL6773648 | 0.83 | TLR7 (0.48) | TLR7TLR8ALDH1A1MEN1KMT2A | |
| SCHEMBL6779814 | 0.83 | FAAH (0.47) | TLR7TLR8MAPKAPK2ALDH1A1KMT2A | |
| SCHEMBL6779049 | 0.83 | DRD2 (0.45) | TLR7TLR8MEN1CYP1A2CYP3A4 | |
| SCHEMBL6778794 | 0.83 | SMN1; SMN2 (0.48) | TLR7TLR8SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6773147 | 0.82 | TLR7 (0.45) | TLR7TLR8NUDT1 | |
| SCHEMBL6286196 | 0.82 | TLR7 (0.45) | TLR7TLR8NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720334-B2 | IMMUNE RESPONSE MODIFIERS; CYTOKINE BIOSYNTHESIS; VIRAL AND NEOPLASTIC DISEASES; 1-(4-(4-AMINO-6,7-DIMETHYL-1H-IMIDAZO (4,5-C)PYRIDIN-1-YL)BUTYL)-3-PHENYLUREA. | 3M INNOVATIVE PROPERTIES COMPANY | 2004-04-13 | — | — | US | claimed |