Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728506 | 0.86 | ESR1 (0.43) | NPC1RAB9AHSP90AA1PTPN1MAPT | |
| SCHEMBL6772444 | 0.83 | TRIM24 (0.47) | NPC1HSP90AA1PTGS2PTGS1PDE3A | |
| SCHEMBL5731027 | 0.80 | PTGS2 (0.60) | HSP90AA1PTGS2PTGS1PDE3AESR1 | |
| SCHEMBL5730530 | 0.80 | PTGS2 (0.60) | HSP90AA1PTGS2PTGS1PDE3AESR1 | |
| SCHEMBL7662650 | 0.75 | CHEK2 (0.42) | PTGS2 | |
| SCHEMBL8460808 | 0.74 | ALDH1A1 (0.57) | NPC1RAB9ALMNACYP1A2PGR | |
| SCHEMBL5730307 | 0.74 | MEN1 (0.49) | NPC1HSP90AA1PTGS2PTGS1PDE3A | |
| SCHEMBL5729425 | 0.74 | MEN1 (0.49) | NPC1HSP90AA1PTGS2PTGS1PDE3A | |
| SCHEMBL8458703 | 0.73 | NPC1 (0.59) | NPC1RAB9ALMNACYP1A2PGR | |
| SCHEMBL8458977 | 0.73 | NPC1 (0.59) | NPC1RAB9ALMNACYP1A2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743815-B2 | OSTEOPOROSIS; ENDOMETRIOSIS; ALZHEIMER'S DISEASE | CHIRON CORPORATION | 2004-06-01 | — | — | US | claimed |