Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650998 | 0.80 | CFD (0.39) | MRGPRX4PTPN1FFAR4SGMS2AKR1B1 | |
| SCHEMBL2650837 | 0.76 | IDO1 (0.51) | — | |
| SCHEMBL15831225 | 0.72 | IDO1 (0.38) | MRGPRX4PTPN1FFAR4SGMS2SLC6A2 | |
| SCHEMBL18722707 | 0.69 | FFAR4 (0.35) | MRGPRX4PTPN1FFAR4SGMS2SLC6A2 | |
| SCHEMBL27606094 | 0.69 | HDAC7 (0.42) | AOC3ACP3MEN1KMT2ASLC6A2 | |
| SCHEMBL27625109 | 0.68 | ACP3 (0.40) | AOC3ACP3MEN1KMT2ASLC6A2 | |
| SCHEMBL7498120 | 0.67 | MMP1 (0.45) | MEN1KMT2AKCNJ5KCNJ3 | |
| SCHEMBL6204740 | 0.67 | AOC3 (0.50) | AOC3ACP3MEN1KMT2ASLC6A2 | |
| SCHEMBL15834275 | 0.67 | IDO1 (0.41) | MRGPRX4PTPN1FFAR4SGMS2MEN1 | |
| SCHEMBL25883966 | 0.66 | FFAR4 (0.45) | MRGPRX4PTPN1FFAR4SGMS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677379-B2 | SUCH AS 3-((3-(3-TRIFLUOROMETHOXYPHENOXY)PHENYL)((3-(1,1,2,2-TETRAFLUOROETHOXY) -PHENYL)METHYL) AMINO)-1,1,1-TRIFLUORO-2-PROPANOL FOR TREATMENT OF CORONARY ARTERY DISEASE | PHARMACIA CORPORATION | 2004-01-13 | — | — | US | claimed |