Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763547 | 0.87 | TSHR (0.56) | TSHRSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL10209975 | 0.82 | L3MBTL1 (0.47) | SMN1; SMN2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL6763567 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1MAPTGAAALOX15 | |
| SCHEMBL10599026 | 0.78 | TSHR (0.70) | TSHRSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL13415005 | 0.77 | TSHR (0.57) | TSHRSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL6767362 | 0.76 | PDE3B (0.65) | SMN1; SMN2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL7788580 | 0.76 | TSHR (0.67) | TSHRSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL6768232 | 0.74 | GAA (0.47) | KDM4EALDH1A1MAPTGAAALOX15 | |
| SCHEMBL12332829 | 0.74 | GAA (0.54) | SMN1; SMN2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL6768134 | 0.74 | NLRP3 (0.41) | TSHRSMN1; SMN2KDM4ECYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699880-B1 | STIMULATE MUSCARINIC ACETYLCHOLINE RECEPTORS M4, ANALGESICS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-03-02 | — | — | US | disclosed |
| EP-1221443-A1 | SUBSTITUTED IMIDAZOLIDINONE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2002-07-10 | — | — | EP | disclosed |