Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27447213 | 0.82 | PREP (0.34) | PREPCELA1KDM4EHSD17B10HTT | |
| SCHEMBL6768198 | 0.81 | ABCB11 (0.36) | KDM4EHSD17B10HTTTP53GAA | |
| SCHEMBL8368621 | 0.78 | PREP (0.32) | PREPCELA1 | |
| SCHEMBL8821099 | 0.76 | PREP (0.42) | PREPCELA1KDM4EHSD17B10HTT | |
| SCHEMBL6773536 | 0.73 | KDM4E (0.33) | KDM4EPOLB | |
| SCHEMBL8368654 | 0.73 | KDM4E (0.40) | PREPCELA1KDM4EHSD17B10HTT | |
| SCHEMBL9507056 | 0.72 | LMNA (0.44) | PREPCELA1KDM4EHSD17B10HTT | |
| SCHEMBL2741240 | 0.70 | CA2 (0.35) | POLBALDH1A1 | |
| SCHEMBL13134484 | 0.70 | LMNA (0.42) | PREPCELA1KDM4EHSD17B10HTT | |
| SCHEMBL4459372 | 0.69 | CYP3A4 (0.42) | PREPCELA1KDM4EHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686389-B2 | KIDNEY DISEASE, ORGAN TRANSPLANT | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-02-03 | — | — | US | disclosed |
| US-20020156296-A1 | 2,3-dihydrobenzofuran derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-10-24 | — | — | US | disclosed |
| US-6403639-B1 | POTENT CYTOPROTECTIVE AGENT WHICH INHIBITS LIPID-PEROXIDATION FOR PREVENTION AND TREATMENT OF VARIOUS RENAL DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-0995437-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156296-A1 | 2,3-dihydrobenzofuran derivatives | CBR1, CYP2F1, NDUFAF2 | PREP 4121/4885CELA1 916/4885KDM4E 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.