Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326430 | 0.90 | THRB (0.47) | THRBTHRACA12CA9ALDH1A1 | |
| SCHEMBL6326453 | 0.87 | CA12 (0.49) | THRBTHRACA12CA9ALDH1A1 | |
| SCHEMBL6323083 | 0.86 | ALDH1A1 (0.54) | THRBTHRACA12CA9ALDH1A1 | |
| SCHEMBL6325872 | 0.82 | THRB (0.50) | THRBTHRACA12CA9ALDH1A1 | |
| SCHEMBL6326427 | 0.80 | THRB (0.47) | THRBTHRACA12CA9ALDH1A1 | |
| SCHEMBL7414482 | 0.78 | MMP3 (0.51) | ALDH1A1MMP3BMP1GAAMMP2 | |
| SCHEMBL6323724 | 0.78 | THRB (0.48) | THRBTHRACA12CA9ALDH1A1 | |
| SCHEMBL6330653 | 0.76 | MMP3 (0.51) | THRBALDH1A1MMP3LMNASMN1; SMN2 | |
| SCHEMBL6331601 | 0.76 | ALDH1A1 (0.54) | THRBTHRACA12CA9ALDH1A1 | |
| SCHEMBL6324038 | 0.76 | MMP3 (0.52) | THRBTHRAALDH1A1MMP3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6747027-B1 | SELECTIVELY INHIBITS IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-13 OVER IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-1 | PHARMACIA CORPORATION | 2004-06-08 | — | — | US | disclosed |