Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | BMP1 | P13497 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.48 |
| ▸ | MMP13 | P45452 | 10/20 | 0.47 |
| ▸ | MMP2 | P08253 | 6/20 | 0.47 |
| ▸ | MMP1 | P03956 | 6/20 | 0.46 |
| ▸ | MMP9 | P14780 | 6/20 | 0.46 |
| ▸ | MMP7 | P09237 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323083 | 0.85 | ALDH1A1 (0.54) | MMP3BMP1ALDH1A1USP2 | |
| SCHEMBL6626956 | 0.83 | MMP3 (0.75) | MMP3BMP1ALDH1A1ADAM17MMP13 | |
| SCHEMBL6675605 | 0.83 | ADAM17 (0.47) | MMP3BMP1ALDH1A1ADAM17MMP13 | |
| Hydrochloric Acid SCHEMBL3938385 | 0.83 | MMP3 (0.73) | MMP3BMP1ALDH1A1ADAM17MMP13 | |
| SCHEMBL6508689 | 0.81 | MMP13 (0.53) | MMP3BMP1ALDH1A1ADAM17MMP13 | |
| SCHEMBL3944994 | 0.81 | ADAM17 (0.50) | MMP3BMP1ALDH1A1ADAM17MMP13 | |
| SCHEMBL6504827 | 0.81 | MMP13 (0.55) | MMP3BMP1ALDH1A1ADAM17MMP13 | |
| SCHEMBL3943732 | 0.81 | MMP13 (0.66) | MMP3BMP1ADAM17MMP13MMP2 | |
| Hydrochloric Acid SCHEMBL6498659 | 0.80 | MMP13 (0.65) | MMP3BMP1ADAM17MMP13MMP2 | |
| SCHEMBL6625705 | 0.79 | ADAM17 (0.46) | MMP3BMP1ADAM17MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149074-A1 | ACETYLENIC SULFONAMIDE THIOL TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000044716-A1 | ACETYLENIC SULFONAMIDE THIOL TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |