Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776254 | 0.88 | CD38 (0.41) | AURKARPS6KB1PARP1PARP2ALDH1A1 | |
| SCHEMBL6782214 | 0.88 | PARP1 (0.39) | AURKARPS6KB1PARP1PARP2PLA2G2A | |
| SCHEMBL6776238 | 0.86 | CD38 (0.38) | AURKARPS6KB1PARP1PARP2ALDH1A1 | |
| SCHEMBL6888996 | 0.85 | TSHR (0.46) | ALDH1A1TSHRKDM4EHPGDHSD17B10 | |
| SCHEMBL6693243 | 0.85 | ALDH1A1 (0.47) | AURKARPS6KB1ALDH1A1TSHRKDM4E | |
| SCHEMBL6693619 | 0.85 | ALDH1A1 (0.47) | AURKARPS6KB1ALDH1A1TSHRKDM4E | |
| SCHEMBL6691170 | 0.85 | PLA2G2A (0.46) | AURKARPS6KB1PARP1ALDH1A1TSHR | |
| SCHEMBL6770455 | 0.85 | CD38 (0.38) | AURKARPS6KB1PARP1PARP2ALDH1A1 | |
| SCHEMBL6771780 | 0.84 | IKBKB (0.37) | AURKARPS6KB1PARP1PARP2PLA2G2A | |
| SCHEMBL6690888 | 0.84 | MEN1 (0.47) | AURKARPS6KB1ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |