Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 3/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776472 | 0.88 | PLA2G2A (0.44) | ALDH1A1MEN1KMT2ALMNAMAP3K14 | |
| SCHEMBL6776614 | 0.88 | PLA2G2A (0.44) | ALDH1A1MEN1KMT2ALMNAMAP3K14 | |
| SCHEMBL6691708 | 0.87 | LMNA (0.48) | ALDH1A1MEN1KMT2ALMNAPLA2G2A | |
| SCHEMBL30409640 | 0.86 | PLA2G2A (0.48) | ALDH1A1MEN1KMT2ALMNAMAP3K14 | |
| SCHEMBL29029759 | 0.86 | PLA2G2A (0.48) | ALDH1A1MEN1KMT2ALMNAMAP3K14 | |
| SCHEMBL6777226 | 0.86 | ADRA1D (0.43) | ALDH1A1MEN1KMT2ALMNAMAP3K14 | |
| SCHEMBL6771810 | 0.86 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ALMNAMAP3K14 | |
| SCHEMBL6688455 | 0.85 | MAPT (0.48) | ALDH1A1MEN1KMT2ALMNAPLA2G2A | |
| SCHEMBL6693619 | 0.85 | ALDH1A1 (0.47) | ALDH1A1KMT2ALMNAPLA2G2ANOD2 | |
| SCHEMBL6774411 | 0.85 | AURKA (0.41) | ALDH1A1MEN1KMT2APLA2G2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |