Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.46 |
| ▸ | MMP2 | P08253 | 7/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.46 |
| ▸ | MMP1 | P03956 | 11/20 | 0.44 |
| ▸ | MMP3 | P08254 | 6/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 5/20 | 0.42 |
| ▸ | MMP9 | P14780 | 4/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6774541 | 1.00 | MMP13 (0.46) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6768858 | 0.90 | MMP13 (0.49) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6768852 | 0.90 | MMP13 (0.49) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6768859 | 0.81 | MMP13 (0.47) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6768854 | 0.81 | MMP13 (0.47) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6769235 | 0.81 | MMP13 (0.62) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6769232 | 0.81 | MMP13 (0.62) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6770700 | 0.80 | MMP1 (0.57) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6770703 | 0.80 | MMP1 (0.57) | MMP13MMP2ADAM17MMP1MMP3 | |
| SCHEMBL6765886 | 0.80 | MMP13 (0.46) | MMP13MMP2ADAM17MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686355-B2 | TREATING HEART DISEASE, MULTIPLE SCLEROSIS, ARTHRITIS, ATHEROSCLEROSIS, AND OSTEOPOROSIS; ANTICANCER AGENTS | WARNER-LAMBERT COMPANY | 2004-02-03 | — | — | US | disclosed |
| US-20020156074-A1 | Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors | BARVIAN NICOLE CHANTEL (US) | 2002-10-24 | — | — | US | disclosed |
| EP-1233016-A1 | Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-08-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156074-A1 | Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors | MMP3, MMP9, MMP13 | MMP13 3/4885MMP2 7/4885ADAM17 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.