Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777696 | 0.90 | PLA2G2A (0.47) | PLA2G2APARP1 | |
| SCHEMBL6691732 | 0.90 | ADRA1D (0.44) | ALDH1A1MEN1KMT2AL3MBTL1ADRA1D | |
| SCHEMBL6770304 | 0.89 | CNR1 (0.42) | ALDH1A1MEN1KMT2AL3MBTL1ADRA1D | |
| SCHEMBL6693347 | 0.89 | PLA2G2A (0.51) | ALDH1A1MEN1KMT2AL3MBTL1ADRA1D | |
| SCHEMBL6776827 | 0.88 | PLA2G2A (0.53) | ALDH1A1MEN1KMT2AL3MBTL1ADRA1D | |
| SCHEMBL6777588 | 0.88 | F10 (0.40) | PLA2G2AF10PARP1PARP2MAPK8 | |
| SCHEMBL6774816 | 0.88 | LMNA (0.43) | L3MBTL1PLA2G2AF10MAPTMAPK8 | |
| SCHEMBL6889689 | 0.88 | MAPT (0.47) | ALDH1A1MEN1KMT2AL3MBTL1F10 | |
| SCHEMBL6777282 | 0.88 | PLA2G2A (0.41) | PLA2G2A | |
| SCHEMBL6773912 | 0.88 | PLA2G2A (0.45) | PLA2G2AF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |