Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773827 | 0.89 | PPARG (0.39) | F10PARP1PARP2PLA2G2AMAPK8 | |
| SCHEMBL6777696 | 0.89 | PLA2G2A (0.47) | PARP1PLA2G2A | |
| SCHEMBL6895193 | 0.89 | POLB (0.39) | F10MAPK8POLBERCC5FEN1 | |
| SCHEMBL6775492 | 0.88 | PLA2G2A (0.41) | F10PARP1PARP2PLA2G2AMAPK8 | |
| SCHEMBL6774766 | 0.88 | ALDH1A1 (0.43) | F10PARP1PARP2PLA2G2AMAPK8 | |
| SCHEMBL6778315 | 0.88 | F10 (0.46) | F10PARP1PARP2PLA2G2AMAPK8 | |
| SCHEMBL6776827 | 0.88 | PLA2G2A (0.53) | F10PLA2G2A | |
| SCHEMBL6774816 | 0.88 | LMNA (0.43) | F10PLA2G2AMAPK8POLBFEN1 | |
| SCHEMBL6777282 | 0.87 | PLA2G2A (0.41) | PLA2G2A | |
| SCHEMBL6773912 | 0.87 | PLA2G2A (0.45) | F10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |