Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 6/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776400 | 0.92 | MAPT (0.45) | PPARGICMTMAPTMAPK10F10 | |
| SCHEMBL6690152 | 0.89 | KDM4E (0.43) | L3MBTL1ICMTPLA2G1BATG4BMAPT | |
| SCHEMBL6776758 | 0.88 | PLA2G2A (0.50) | L3MBTL1PLA2G1BATG4BMAPTMAPK10 | |
| SCHEMBL6890365 | 0.88 | PPARG (0.46) | PPARGL3MBTL1HTTMAPTMAPK10 | |
| SCHEMBL6690216 | 0.88 | PLA2G2A (0.43) | PPARGL3MBTL1PLA2G1BPARP1PLA2G2A | |
| SCHEMBL6772770 | 0.88 | PLA2G2A (0.41) | L3MBTL1ICMTPLA2G1BATG4BMAPT | |
| SCHEMBL6776773 | 0.87 | PLA2G2A (0.42) | PPARGPLA2G1BPLA2G2A | |
| SCHEMBL7966203 | 0.86 | PLA2G2A (0.46) | PPARGPLA2G1BPLA2G2A | |
| SCHEMBL6693716 | 0.86 | F10 (0.48) | PPARGL3MBTL1ICMTPLA2G1BATG4B | |
| SCHEMBL6775434 | 0.86 | ADRA1D (0.46) | L3MBTL1ICMTPLA2G1BATG4BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |