Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6774185 | 0.91 | TP53 (0.47) | ADRA1DPLA2G2AALDH1A1MAPTTP53 | |
| SCHEMBL6776758 | 0.91 | PLA2G2A (0.50) | ADRA1DPLA2G2AALDH1A1KDM4EMAPT | |
| SCHEMBL6690216 | 0.91 | PLA2G2A (0.43) | ADRA1DPLA2G2AALDH1A1POLBMEN1 | |
| SCHEMBL6776773 | 0.89 | PLA2G2A (0.42) | PLA2G2AALDH1A1PLA2G1B | |
| SCHEMBL6890338 | 0.89 | MAPT (0.44) | PLA2G2AALDH1A1KDM4EMAPTTP53 | |
| SCHEMBL6776710 | 0.88 | PLA2G2A (0.41) | ADRA1DPLA2G2AF10L3MBTL1PARP1 | |
| SCHEMBL6772770 | 0.88 | PLA2G2A (0.41) | ADRA1DPLA2G2AALDH1A1KDM4EMAPT | |
| SCHEMBL6771677 | 0.87 | PLA2G2A (0.41) | ADRA1DPLA2G2AALDH1A1L3MBTL1PLA2G1B | |
| SCHEMBL6691732 | 0.87 | ADRA1D (0.44) | ADRA1DPLA2G2AALDH1A1MAPTPOLB | |
| SCHEMBL6775381 | 0.86 | PPARG (0.44) | PLA2G2AMAPTF10L3MBTL1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |